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UnknownConditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta.
Suprarenal aortic clamping during abdominal aortic aneurysm (AAA) repair results in ischemia-reperfusion injury (IRI) in local (i.e. kidney) and distant (i.e. heart) tissue. To investigate perioperative approaches that mitigate IRI-induced tissue damage, Wistar rats underwent suprarenal aortic clamp...
S-EPMC7081351 | biostudies-literature
TranscriptomicsThe stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Transcriptional profiling of control and MKK7-deficient primary mouse pneumocytes after oncogenic KRasG12 induction Two-condition experiment, MKK7 proficient vs. MKK7 deficient pneumocytes. 3 Biological replicates: 3 control, 3 knock out, independently grown and harvested. 3 technical replicates p...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26763 | biostudies-arrayexpress
UnknownBiological Response of Human Cancer Cells to Ionizing Radiation in Combination with Gold Nanoparticles.
In the context of improving radiation therapy, high-atomic number (Z) metallic nanoparticles and, more importantly, gold-based nanostructures are developed as radiation enhancers/radiosensitizers. Due to the diversity of cell lines, nanoparticles, as well as radiation types or doses, the resulting b...
S-EPMC9600885 | biostudies-literature
UnknownLATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.
Deregulated activity of LArge Tumor Suppressor (LATS) tumor suppressors has broad implications on cellular and tissue homeostasis. We examined the consequences of down-regulation of either LATS1 or LATS2 in breast cancer. Consistent with their proposed tumor suppressive roles, expression of both par...
S-EPMC6238411 | biostudies-literature
Unknownp53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner.
Intercellular adhesion molecule-1 (ICAM-1) is a crucial receptor in the cell-cell interaction, a process central to the reaction to all forms of injury. Its expression is upregulated in response to a variety of inflammatory/immune mediators, including cellular stresses. The NF-kappaB signalling path...
S-EPMC152901 | biostudies-literature
UnknownNanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines.
Cervical cancer remains a pressing global health concern, necessitating advanced therapeutic strategies. Radiotherapy, a fundamental treatment modality, has faced challenges such as targeted dose deposition and radiation exposure to healthy tissues, limiting optimal outcomes. To address these hurdle...
S-EPMC10742116 | biostudies-literature
UnknownA GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.

Background

Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast ma...
S-EPMC10386253 | biostudies-literature
UnknownMutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures. Remarkably, whe...
S-EPMC3657134 | biostudies-literature
UnknownModulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.
Osteosarcoma is the most common primary bone cancer. Mutations of the RB gene represent the most frequent molecular defect in this malignancy. A major consequence of this alteration is that the activity of the key cell cycle regulator E2F1 is unleashed from the inhibitory effects of pRb. Studies in ...
S-EPMC2708823 | biostudies-literature
UnknownMutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.
Emerging notion in carcinogenesis ascribes tumor initiation and aggressiveness to cancer stem cells (CSCs). Specifically, colorectal cancer (CRC) development was shown to be compatible with CSCs hypothesis. Mutations in p53 are highly frequent in CRC, and are known to facilitate tumor development an...
S-EPMC6448595 | biostudies-literature
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