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TranscriptomicsIdentification of copy number alterations associated with the progression of DCIS to Invasive Ductal Carcinoma
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma (IDC). Annotation of the genetic differences between the two lesions may assist in the identification of genes that promote the invasive phenotype. Matched IDC and DCIS showed highly similar copy number profile...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-31892 | biostudies-arrayexpress
TranscriptomicsCopy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumour tissue
We analysed a cohort of Lifepool IDC cases treated only with wide local excision for genome-wide copy number and loss of heterozygosity using Affymetrix OncoScan® MIP arrays. Cases included IDC (n=4).Benign cases were available for 2 cases. We have analysed copy number calling from the same samples...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85035 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genome-wide copy number analysis of low grade serous ovarian tumours
Integration of genomic copy number analysis (Affymetrix SNP6.0 arrays) and oncogenic RAS/RAF mutation status with clinical features and tumour progression. This study found that loss of the 9p and the CDKN2A locus with the most significantly enriched copy number aberration distinguishing serous bord...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-58579 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genome-wide copy number analysis of pre-invasive mucinous ovarian tumours
Introduction: Mucinous tumors are the second most common form of epithelial ovarian tumor, yet the cell of origin for this histological sub-type remains undetermined. While these tumors are thought to arise through a stepwise progression from benign cystadenoma to borderline tumor to invasive carcin...
ORGANISM(S): Homo sapiens 
2012-08-26 | E-GEOD-39076 | biostudies-arrayexpress
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