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TranscriptomicsMultidrug Resistance-Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma
This study assesses the ability of multidrug resistance (MDR)-associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large set of genes was evaluated wh...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-30009 | biostudies-arrayexpress
TranscriptomicsClinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions
The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient s...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-29702 | biostudies-arrayexpress
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
TranscriptomicsIndividual multidrug resistance patterns in AML patients point to the need for personalized molecular analysis
In this unique study, based on paired samples obtained at AML diagnosis and at relapse, we assessed 380 multidrug-resistance-related genes, using TaqMan-based qRT-PCR, as indicated by reports published over the past three decades. 11 paired AML samples taken at diagnosis and at relapse after treatme...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-33787 | biostudies-arrayexpress
TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
Transcriptomicsdocetaxel response predic Illumina
Using gene expression profiling of mammary tumors generated in a mouse model for BRCA1-associated breast cancer we have searched for markers that correlate with response to the anti-cancer drugs docetaxel or cisplatin. To validate the results, the analysis was done on 2 different platforms (39K Mous...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-413 | biostudies-arrayexpress
Transcriptomicsdocetaxel response prediction MEEBO
Using gene expression profiling of mammary tumors generated in a mouse model for BRCA1-associated breast cancer we have searched for markers that correlate with response to the anti-cancer drugs docetaxel or cisplatin. To validate the results, the analysis was done on 2 different platforms (39K Mous...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-415 | biostudies-arrayexpress
UnknownAssociation of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection.
Not available
S-EPMC10403154 | biostudies-literature
UnknownGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535838 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
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