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MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
UnknownElectronic cigarette use among adult population: a cross-sectional study in Barcelona, Spain (2013-2014).
Not available
S-EPMC4156815 | biostudies-literature
ModelsShlomi2011 - Warburg effect, metabolic model
Shlomi2011 - Warburg effect, metabolic model Using a genome-scale human metabolic network model accounting for stoichiometric and enzyme solvent capacity considerations, this model shows that the Warburg effect (a classical hallmark of cancer metabolism) is a direct consequence of...
2005-01-01 | MODEL1105100000 | BioModels
UnknownMetabolic adaptation to consume butyrate under prolonged resource exhaustion.
Not available
S-EPMC10321620 | biostudies-literature
Unknown"Tobacco-free nicotine" electronic cigarette perceptions and use among adolescents and adults in five New England states.
Not available
S-EPMC10788778 | biostudies-literature
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
UnknownMechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.
Not available
S-EPMC9455988 | biostudies-literature
UnknownMyosin-binding Protein C Compound Heterozygous Variant Effect on the Phenotypic Expression of Hypertrophic Cardiomyopathy.
Not available
S-EPMC5421475 | biostudies-literature
UnknownGenomic profiling of Escherichia coli isolates from bacteraemia patients: a 3-year cohort study of isolates collected at a Sydney teaching hospital.
Not available
S-EPMC7371115 | biostudies-literature
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