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ProteomicsAutophosphorylation of the CK1 kinase domain regulates enzyme activity and substrate specificity
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe a new mechanism of CK1 regulation conserved from yeast to human – autopho...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-07-20 | PXD026766 | Pride
Casein kinase 1 Ck1 S. pombe Substrate specificity Kinase regulation 
ProteomicsFission yeast DUB substrates - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival
His-Biotin-His Ubiquitin was overexpressed in various fission yeast (S. pombe) genetic backgrounds to identify ubiqutinated proteins. Normalizing to bait (ubiquitin) across samples provided insight into relative changes in ubiquitination with loss of deubiquitinases (DUBs), yielding putative DUB sub...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-09 | PXD001767 | Pride
Ubiquitin deubiquitinases fission yeast ubiquitination 
ProteomicsCK1 promotes double-strand break repair in fission yeast
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. The C-termini of these enzymes are thought to inhibit kinase activity by acting as pseudosu...
ORGANISM(S): Schizosaccharomyces pombe 
2025-05-06 | PXD033223 | Pride
Casein kinase 1 Ck1 Kinase substrates S. pombe Kinase regulation 
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