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GenomicsTcf-1 expression in murine thymus
The DNA binding factor Tcf-1 is one of the most prominently expressed genes in thymocytes yet it's global DNA binding pattern remained unknown. Here we have assessed by ChIP-seq the Tcf-1 binding pattern in murine thymocytes. Tcf-1 ChIP-seq of 1 sample and input control.
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-46662 | biostudies-arrayexpress
TranscriptomicsT cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. Activation of Notch signaling in uncommitted precursors by the thymic strom...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33513 | biostudies-arrayexpress
TranscriptomicsHarnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis
Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2u Nucleosome Remodeling and Deacetylase (NuRD) complex is controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component ...
ORGANISM(S): Mus musculus 
2011-11-13 | E-GEOD-32311 | biostudies-arrayexpress
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