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ProteomicsA rapid, tag-free way to purify functional GPCRs
A GPCR purification method is described based on how the Galpha-CT (alpha5 helix) interacts with G-protein coupled receptors (GPCRs). The importance of this region in binding to and stabilizing the active GPCR state (R*) is well established, as it plays a conserved role in allosterically linking R* ...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2024-05-22 | PXD046070 | Pride
In-gel digestion Affinity purification Mass spectrometry Gpcp purification Protein identification 
GenomicsEndocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs
Endocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs
PRJNA1225749 | ENA
ModelsNair2015 - Interaction between neuromodulators via GPCRs - Effect on cAMP/PKA signaling (D1 Neuron)
Nair2015 - Interaction between neuromodulators via GPCRs - Effect on cAMP/PKA signaling (D1 Neuron) This model is described in the article: Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny ...
2024-09-02 | BIOMD0000000635 | BioModels
ModelsNair2015 - Interaction between neuromodulators via GPCRs - Effect on cAMP/PKA signaling (D2 Neuron)
Nair2015 - Interaction between neuromodulators via GPCRs - Effect on cAMP/PKA signaling (D2 Neuron) This model is described in the article: Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny ...
2024-09-02 | BIOMD0000000636 | BioModels
GenomicsChimeric GPCRs mimic distinct signaling pathways and modulate microglia responses
Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses
PRJNA799252 | ENA
TranscriptomicsEndocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs
Many G protein-coupled receptors (GPCRs) trigger a second phase of G protein-dependent signaling from internal membranes after agonist-induced endocytosis. However, individual GPCRs differ significantly in their ability to internalize after activation, and it remains unclear if this confers selectiv...
ORGANISM(S): Homo sapiens 
2025-02-24 | GSE290019 | GEO
Genomicsundefined
Identification of GPCRs from Phytophthora agathidicida genome
PRJEB62717 | ENA
UnknownDAKB-GPCRs: An Integrated Computational Platform for Drug Abuse Related GPCRs.
Not available
S-EPMC6758544 | biostudies-literature
GenomicsTargeting class A GPCRs for hard tissue regeneration
Targeting class A GPCRs for hard tissue regeneration
PRJNA899007 | ENA
UnknownG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs.
Not available
S-EPMC4805599 | biostudies-literature
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