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ProteomicsAffimer reagents as tools to modulate GPVI-ligand interactions
We have isolated Affimers that bind to GPVI and characterized their effect on receptor function. An affimer that binds specifically to dimeric GPVI was identified as a novel tool to detect dimeric GPVI. The binding sites of the different Affimers were mapped using HDX-MS, revealing that they interac...
ORGANISM(S): Homo sapiens (Human) 
2024-10-01 | PXD046982 | Pride
Hdx-ms Gpvi 
UnknownCharacterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation.
Not available
S-EPMC8744670 | biostudies-literature
UnknownAffimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer.
Not available
S-EPMC11321386 | biostudies-literature
UnknownAnti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation.
Not available
S-EPMC9804350 | biostudies-literature
UnknownClustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.
Not available
S-EPMC5347898 | biostudies-literature
UnknownRac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation.
Not available
S-EPMC8998833 | biostudies-literature
UnknownDifferential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies.
Not available
S-EPMC4452546 | biostudies-literature
ProteomicsIntegrated phosphoproteomic profiling and causal analysis reveal signaling relations in GPVI/ITAM-mediated platelet activation programs
Platelets engage cues of pending endothelial dysfunction through coordinated adhesion, secretion and aggregation responses. These rapid changes in platelet phenotype are orchestrated by intracellular mechanisms that remain systematically undefined. This study develops a TMT-SPS-MS3 phosphoproteomics...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD017167 | Pride
Human Platelets Causal pathways Cardiovascular disease Isobaric labeling Activation Phosphopeptide enrichment Quantitative proteomics Signaling 
UnknownTargeting platelet GPVI with glenzocimab: a novel mechanism for inhibition.
Not available
S-EPMC10119634 | biostudies-literature
UnknownmTOR regulates GPVI-mediated platelet activation.
Not available
S-EPMC8111939 | biostudies-literature
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