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TranscriptomicsComparison of miRNA profile of natural T reg cells with conventional CD4+CD25- T cells
Low molecular weight RNA from conventional T cells and T reg cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell type comparison Six arrays representing three biological replicates and dyeswaps of each.
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6003 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile of activated T cells to naive T cells
T cells were activated for 1, 3 or 10 days using plate-bound anti-TCR and anti-CD28. Low molecular weight RNA from conventional T cells and activated T cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell state analysis Five arr...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6006 | biostudies-arrayexpress
UnknownThe human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
Not available
S-EPMC16840 | biostudies-literature
TranscriptomicsExpression data from from hTR and hTERT knockdown in human CD4 T cells
We have found that knockdown of the human telomerase RNA template, hTR, induces Bim-mediated apoptosis independent of telomere length in primary human CD4 T cells, whereas knockdown of the telomerase enzymatic protein, hTERT does not induce apoptosis in the timeframe of our studies. We used microarr...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-60855 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile of Foxp3-transduced activated T cells with control vector-transduced activated T cells
Activated T cells were transduced with either Foxp3-IRES-GFP or IRES-GFP control vector. Low molecular weight RNA from cells was extracted 72h or 96h later and hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell type comparison Four arra...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6007 | biostudies-arrayexpress
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD035699 | Pride
Cutaneous t-cell lymphoma Kinases 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035626 | Pride
Global proteomics Kinase Cutaneous t-cell lymphomas (l-ctcl) 
TranscriptomicsA role for Dicer in immune regulation
A study of the miRNA profile CD4 T cells compared to T reg cells; of activated and naive T cells; and the miRNA profile conferred by enforced expression of Foxp3. Keywords: cell type comparison Fifteen arrays broken down into three broader experiments as referenced by series GSE6003 - a comparison o...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6056 | biostudies-arrayexpress
UnknownBCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
Not available
S-EPMC10620766 | biostudies-literature
UnknownMutational spectrum of adult T-ALL.
Not available
S-EPMC4413615 | biostudies-literature
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