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Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability
This study investigates the proteomic dynamics of human liver grafts during normothermic machine perfusion (NMP), using mass spectrometry-based analysis. A total of 16 donor livers were perfused with NMP and sampled at three distinct time points to assess molecular changes and their association with...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD067270 | Pride
Acute graft versus host disease is a serious condition caused by allo-reactive donor CD4+ T cells from allogenic hematopoietic stem cell transplantation. To understand the developmental relationships between T-helper states in mesenteric lymph nodes (mLN), TCR transgenic CD4+ T cells specific for a ...
ORGANISM(S): Mus musculus 
Activation of donor-derived eosinophils contributes to primary graft dysfunction during static lung graft storage
We developed a humanized mouse model of graft-versus-host disease in which Treg injected two days after PBMC persist in the blood of infused mice and can be characterized. This model provides in vivo assessment of manipulated Treg. We used that model to evaluate the impact of ex vivo priming of Treg...
ORGANISM(S): Homo sapiens 
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