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MetabolomicsPrevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher le...
2026-09-11 | MTBLS15633 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
MetabolomicsHost NLRP6 exacerbates graft-versus-host disease independent of microbial diversity
Not available
ORGANISM(S): Mus musculus 
ST001089 | MetabolomicsWorkbench
MetabolomicsT cell metabolism during graft-versus-host disease(CAB 311)
Not available
ORGANISM(S): Mus musculus 
ST000181 | MetabolomicsWorkbench
MetabolomicsT cell metabolism during graft-versus-host disease (CAB 307)-PART I
Not available
ORGANISM(S): Mus musculus 
ST000178 | MetabolomicsWorkbench
MetabolomicsGut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
Not available
ORGANISM(S): Mus musculus 
ST000338 | MetabolomicsWorkbench
TranscriptomicsGene expression in the thymus medulla in the absence and presence of acute graft-versus-host disease
To investigate gene expression profile of medullary thymic epithelial cells with high surface density of MHC class II (mTEChigh), a murine parent into F1 hematopoietic stem cell transplantation model was administered. As recipient mice (B6xDBA/2)F1 (B6D2F1) were used that received either a syngeneic...
ORGANISM(S): Mus musculus 
2012-12-20 | E-MEXP-3745 | biostudies-arrayexpress
TranscriptomicsSomatic Gain-of-Function mTOR mutation in Clonally Expanded T-lymphocytes Associated with Chronic Graft-Versus-Host Disease
Graft-versus-host-disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GVHD (cGVHD) carrying persistent CD4+ T cell clonal expansion which harbored somatic mTOR, NFKB2, and TLR2 mutations. Functional an...
ORGANISM(S): Homo sapiens 
2020-04-12 | E-MTAB-8911 | biostudies-arrayexpress
TranscriptomicsRNAseq of the small intestine of mice 6 days after they were transplanted with either wildtype allogeneic T cells or glucocorticoid-resistant allogeneic T cells (mouse model of acute graft-versus-host disease
Given that mice transplanted with glucocorticoid-resistant T cells display more severe disease symptoms, the idea was that an RNA-seq comparison between mice transplanted with either wildtype or glucocorticoid-resistant T cells could yield genes involved in disease progression and potential therape...
ORGANISM(S): Mus musculus 
2019-03-12 | E-MTAB-7765 | biostudies-arrayexpress
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