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MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
TranscriptomicsExpression profiling of circulating miRNAs in Luminal A breast cancer
Breast cancer is a common disease with distinct tumor subtypes which can be phenotypically characterized by estrogen receptor, progesterone receptor and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression. Altered miRNA expression has been demonstrated in a var...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-46355 | biostudies-arrayexpress
UnknownA Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype.
Not available
S-EPMC3342980 | biostudies-literature
TranscriptomicsLectin-type oxidized LDL receptor 1 defines population of polymorphonuclear myeloid-derived suppressor cells in cancer patients
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are important regulators of immune responses and promoters of tumor progression in cancer1,2. The heterogeneity of these cells as well as their distinction from neutrophils hampers the progress in understanding of the biology and clinical...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-79404 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
2009-10-26 | E-TABM-759 | biostudies-arrayexpress
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
TranscriptomicsTranscription profiling of genes related to ovary activation in worker honey bee brains
This experiment examines differences in gene expression between wildtype and an experimental strain (anarchistic) of worker honey bees (Apis mellifera). Mature wildtype and anarchistic workers tend to have non-active and active ovaries, respectively. Thus young workers from these strains are expecte...
ORGANISM(S): Apis mellifera 
2008-07-11 | E-MEXP-1552 | biostudies-arrayexpress
GenomicsGenome-wide identification of functional elements regulated by T-bet and GATA3 in human T-cells
T-bet and GATA3 induce differentiation of CD4+ T-cells into Th1 or Th2 effectors. These exhibit a range of different properties but understanding of T-bet and GATA3 function is mostly limited to the murine Ifng and Il4/Il5/Il13 loci. We hypothesised that extending such analyses across the human geno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-31320 | biostudies-arrayexpress
UnknownGenome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia.
Not available
S-EPMC5802589 | biostudies-literature
UnknownSARS CoV-2 seroprevalence in a US school district during COVID-19.
Not available
S-EPMC8551743 | biostudies-literature
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