Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of rat synaptosomes of the hippocampus vs. total hippocampus reveals activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
Mammalian target of rapamycin (mTOR) is implicated in synaptic plasticity and local translation in dendrites. Here we found that the mTOR inhibitor, rapamycin, increased the Kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted Kv1.1 surface expression on dendrites withou...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5516 | biostudies-arrayexpress
MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
UnknownHuman serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.
Not available
S-EPMC5572919 | biostudies-literature
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownHuman Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.
Not available
S-EPMC6424897 | biostudies-literature
TranscriptomicsFolic acid induces cell type-specific changes in the transcriptomes of breast cancer cell lines
The effect of folic acid (FA) on breast cancer (BC) risk is uncertain. We hypothesised that this uncertainty may be due, in part, to differential effects of FA between BC cells with different phenotype. To test this we investigated the effect of treatment with FA concentrations within the range of u...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-68651 | biostudies-arrayexpress
TranscriptomicsPancreatic islet expression profiling in diabetes prone C57BLKS/J mice vs C57BL6/J mice.
C57BLKS/J mice are susceptible to diabetes, because of islet dysfunction, whereas C57BL6/J mice are not. Differences in gene expression between the two strains may account for this sensitivity. Furthermore these differences may only be evident in the hyperstimulated (diabetic or hyperglycemic) state...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-11257 | biostudies-arrayexpress
UnknownVitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study.
Not available
S-EPMC8728359 | biostudies-literature
ProteomicsTD-MS analysis of single-domain antibody and anti-EGFR single-domain antibody-drug conjugate
Analysis of the intact single-domain antibody and its associated anti-EGFR single-domain antibody-drug conjugate. Optimizations of conditions with various fragmentation methods.
ORGANISM(S): Cellular Organisms 
2025-02-11 | PXD058380 | JPOST Repository
TranscriptomicsGRO analysis of rap1-sil, tpk1 & tpk2.
GRO (Genomic run-on) experiments with different mutants that affect to the accumulation of non active RNA pol II along the yeast genome. Keywords: Genomic run-on GRO There are 4 different strains: rap1-sil (without the silencing domain), RAP1(both from Graham I.R. et al 1999) and tpk1 & tpk2 mutant...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14080 | biostudies-arrayexpress
Sort   by:  
 Page size