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TranscriptomicsGene expression breast cancer
Gene expression profiles were generated from 176 primary breast cancer patients and 12 normal breast samples. This data is used to investigate the clinical relevance of genes of interest from in vitro studies, including FABP5 and DDX1. This Series represents RNA isolated from 176 primary breast canc...
ORGANISM(S): Homo sapiens 
2011-04-27 | E-GEOD-22820 | biostudies-arrayexpress
TranscriptomicsGene expression in wild type and mENT1 knock out mice
To investigate the functional importance of a nucleoside transporter, the mENT1 (Slc29a1) was knocked out in mice. The gene expression profile was compared between wildtype and mENT1 knock out mice in two tissues. RNA was isolated from heart and kidney from 3 mENT1 knockout and 3 wildtype (FVB/N) mi...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-22565 | biostudies-arrayexpress
TranscriptomicsEffects of sample size on differential gene expression, rank order and prediction accuracy of a gene signature
Gene expression profiles were generated from muscle biopsies from 134 individuals, and differences in expression based on sex were explored. Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reprodu...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-41726 | biostudies-arrayexpress
TranscriptomicsMGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib
Angiogenesis inhibitors, such as sunitinib, represent a promising strategy to improve glioblastoma (GBM) tumor response. In this study, we used the O6-methylguanine methyltransferase (MGMT)-negative GBM cell line U87MG stably transfected with MGMT (U87/MGMT) to assess whether MGMT expression affects...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40776 | biostudies-arrayexpress
TranscriptomicsDual-mechanism ERK1/2 inhibitors exploit a distinct binding mode to block phosphorylation and nuclear accumulation of ERK1/2, resulting in enhanced potency
Here we have characterized the MoA of Erk inhibitors in terms of Erk1/2 signalling, gene expression and antiproliferative efficacy in BRAF and RAS mutant cell lines.
ORGANISM(S): Homo sapiens 
2020-10-08 | E-MTAB-7959 | biostudies-arrayexpress
TranscriptomicsModulator of Apoptosis 1 (MOAP-1) is a highly regulated tumor suppressor protein
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in both the intrinsic and extrinsic modes of cell death or apoptosis. It is an integral partner to the tumor suppressor Ras association domain family 1A (RASSF1A) and functions to activate the Bcl-2 family pro-apoptotic pro...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-43990 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer
Prognostication of Breast Cancer (BC) relies largely on traditional markers such as hormone or growth factors but due to their suboptimal specificities, it is challenging to identify the subset of patients who are likely to undergo recurrence and markers of higher specificity are sought to guide the...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-68085 | biostudies-arrayexpress
UnknownPrevalence and Correlates of Youth Suicidal Ideation and Attempts: Evidence from the 2014 Ontario Child Health Study.
Not available
S-EPMC6463356 | biostudies-literature
UnknownChanges in the Prevalence of Child and Youth Mental Disorders and Perceived Need for Professional Help between 1983 and 2014: Evidence from the Ontario Child Health Study.
Not available
S-EPMC6463358 | biostudies-literature
UnknownSix-Month Prevalence of Mental Disorders and Service Contacts among Children and Youth in Ontario: Evidence from the 2014 Ontario Child Health Study.
Not available
S-EPMC6463361 | biostudies-literature
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