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ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
ProteomicsDual-acting IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans. The IspH substrate, HMBPP,...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-10-22 | MSV000086359 | MassIVE
TranscriptomicsCritically ill patients with either gram-positive sepsis or gram-negative sepsis
Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A pros...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-6535 | biostudies-arrayexpress
TranscriptomicsProfiling the circulating miRNAs in mice exposed to gram-positive and gram-negative bacteria by Illumina small RNA deep sequencing
We profiled the expression of circulating microRNAs (miRNAs) in mice exposed to gram-positive and gram-negative bacteria using Illumina small RNA deep sequencing. Recombinant-specific gram-negative pathogen Escherichia coli (Xen14) and gram-positive pathogen Staphylococcus aureus (Xen29) were used ...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-60492 | biostudies-arrayexpress
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
TranscriptomicsStrand specific sequencing illustrates the complex transcriptional response of Legionella pneumophila during infection
Legionella pneumophila is a Gram-negative facultative intracellular human pathogen with a distinct biphasic lifestyle. One of its primary environmental hosts in the free-living amoeba Acanthamoeba castellanii and its infection by L. pneumophila mimics that seen in human macrophages. Here we present ...
ORGANISM(S): Legionella pneumophila 
2011-02-11 | E-GEOD-27232 | biostudies-arrayexpress
TranscriptomicsCirculating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice
To explore the circulating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice The recombinant specific Gram negative pathogens Escherichia coli (xen14) and Gram positive pathogens Staphyllococcus aureus (xen29) were purchased from the Caliper (Caliper, P...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-49189 | biostudies-arrayexpress
TranscriptomicsDengue virus inhibits immune responses in Aedes aegypti cells
The ability of many viruses to manipulate the host antiviral immune response often results in complex host-pathogen interactions. In order to study the interaction of dengue virus (DENV) with the Aedes aegypti immune response, we have characterized the DENV infection-responsive transcriptome of the ...
ORGANISM(S): Aedes aegypti 
2011-10-31 | E-GEOD-33274 | biostudies-arrayexpress
TranscriptomicsREG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
Objective: Reg3g has been proposed to have a protective role against infection due to its bactericidal effect on Gram-positive bacteria, but evidence from in vivo studies is lacking. Therefore we generated a Reg3g-/- mouse, to determine its role in intestinal homeostasis and protection against exper...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-44409 | biostudies-arrayexpress
TranscriptomicsBdellovibrio bacteriovorus attack phase and Host-Independent grown cells
Bdellovibrio is a Gram-negative bacterium that preys upon other Gram-negative bacteria, including many pathogens, and as such has potential as a biocontrol agent. Little is known of the molecular and genetic control of Bdellovibrioâ??s attack upon its prey and of the nature of the HI phenotype. Here...
ORGANISM(S): Bdellovibrio bacteriovorus 
2010-05-18 | E-GEOD-16034 | biostudies-arrayexpress
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