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MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
TranscriptomicsGlobal transcriptome of CFA/I expressing ETEC H10407 under in vitro growth and water stress
Enterotoxigeneic Escherichia coli (ETEC) is a leading cause of diarrhoeal infections in young children living in endemic regions in low and middle-income countries and adults travelling to these destinations. CFA/I fimbriae have been identified as the predominant colonisation factor associated with ...
ORGANISM(S): Escherichia coli ETEC H10407 
2021-04-21 | E-MTAB-9364 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsExpression data from breast tumors and reduction mammoplasty explants
Breast tumorigenesis involves modulation of gene expression. We used microarrays to detail the global program of gene expression underlying breast tumorigenesis. Three examples of stage I breast tumor and 3 samples of breast reduction mammoplasty tissue were expanded as explant cultures for RNA extr...
ORGANISM(S): Homo sapiens 
2010-11-17 | E-GEOD-25407 | biostudies-arrayexpress
UnknownTurtling: a time-aware neural topic model on NIH grant data.
Not available
S-EPMC11216609 | biostudies-literature
UnknownCooperative housing under a grant-of-use in Catalonia and health: pre-post analysis.
Not available
S-EPMC11234659 | biostudies-literature
UnknownElements of successful NIH grant applications.
Not available
S-EPMC11009615 | biostudies-literature
GenomicsDeveloping a robust genome editing tool based on an endogenous Type I-B CRISPR-Cas system in Saccharopolyspora spinosa
Developing a robust genome editing tool based on an endogenous Type I-B CRISPR-Cas system in Saccharopolyspora spinosa
PRJNA1165256 | ENA
TranscriptomicsSingle-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients
We evaluated blood samples from 6 patients with metastatic melanoma treated with anti-LAG3+anti-PD1 (160+480 mg) in a phase I trial (NCT01968109) using single-cell RNA and T cell receptor (TCR) sequencing (scRNA+TCRαβ-seq, 10X 5') combined with other multiomics profiling (flow, cytokine, TCRb-seq) f...
ORGANISM(S): Homo sapiens 
2023-02-03 | E-MTAB-12733 | biostudies-arrayexpress
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
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