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Transcriptomicsgranulosa cell tumor vs normal granulosa cells
mRNA expression profiling in human granulosa cell tumor cell line and normal granulosa cells
ORGANISM(S): Homo sapiens 
2012-01-26 | E-MTAB-957 | biostudies-arrayexpress
TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice transgenic for LHCTP hyper secreting luteinizing hormone with cystic ovaries, luteoma or wild type to compare global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas
Comparison of global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas, and identification of new markers for this tumor phenotype. Luteinizing hormone hypersecreting mice studied.
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-499 | biostudies-arrayexpress
TranscriptomicsOvarian granulosa cell tumor and normal granulosa cells transcriptomes
RNA was extracted from normal human granulosa cells from IVF patients (hGC1 and hGC2 samples) and from adult-type ovarian granulosa cell tumor samples (H1, H8, H20, H23, H24, H28, H30, H33, H4, H18) as described in Jamieson et al, 2010. RNA from all samples was linearly amplified using the Whole Tra...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-MTAB-483 | biostudies-arrayexpress
ProteomicsCRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
FOXL2 is a transcription factor that plays a key role in sex determination, ovary development and maintenance. Mutations related to this gene have been described in syndromes involving premature ovarian failure and granulosa cell tumors. This kind of rare cancer (less than 5% of diagnosed ovarian ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-15 | PXD053682 | Pride
Tmt Rare cancer Crispr Granulosa cell tumor Proteomics Foxl2 
TranscriptomicsEither Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis
Stable activation of the WNT signaling effector beta-catenin (CTNNB1(ex3) in ovarian granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life. Loss of the tumor suppressor gene Pten accelerates GCT formation in the CT...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-27656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries from Smad1/5/8 mutant granulosa cell tumor
The objective of this study was to understand the gene expression changes during granulosa cell tumor development in Smad1/5/8 mutant ovaries. Experiment Overall Design: Three independent mouse mutant granulosa cell tumors were compared to three wild type granulosa cells samples.
ORGANISM(S): Mus musculus 
2009-10-20 | E-GEOD-8156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Inhba flox/- Inhbb-/- Amhr2cre/+ activin-deficient granulosa cells vs. wild type
Compares activin deficient granulosa cells (Inhba flox/-; Inhbb-/-; Amhr2cre/+) to wild type granulosa cells Experiment Overall Design: Three replicate wild type granulosa cell samples compared to 2 activin-deficient granulosa cell samples. Each replicate is derived from 2-3 females.
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7150 | biostudies-arrayexpress
TranscriptomicsCharacterization of the granulosa cell tumor transcriptome using RNA-seq
Granulosa cell tumors (GCTs) are rare types of ovarian cancer, consisting of an adult and a juvenile subtype. There has been a lack of research into this specific cancer, especially regarding the differences between the two subtypes. Here we compared the transcriptome of normal ovary (n=1) and GCT (...
ORGANISM(S): Homo sapiens 
2026-05-28 | E-MTAB-14294 | biostudies-arrayexpress
TranscriptomicsGene expression in bovine ovarian follicle granulosa
Granulosa cells mature and die as ovarian follicles enlarge and die (undergo atresia) under the influence of hormones and intrafollicular factors. Later in follicular development, a fluid-filled antrum is formed, a process which is accompanied by a high rate of atresia. These small antral follicles ...
ORGANISM(S): Bos taurus 
2014-05-20 | E-GEOD-39589 | biostudies-arrayexpress
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