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TranscriptomicsFoxl2 functions throughout mouse ovary development
This SuperSeries is composed of the following subset Series: GSE12905: Foxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed by Affymetrix arrays GSE12942: Foxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed ...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12989 | biostudies-arrayexpress
TranscriptomicsFoxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed by Agilent arrays
Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical genes, i.e., Rspo1 and Wnt4. Here we report expression prof...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12942 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FOXL2 over-expression in human KGN cells
In order to identify novel FOXL2 targets, we have transfected KGN cells using an expression vector containing the coding sequence of FOXL2 or, as a reference, the empty vector (mock transfection). The transcriptome perturbation induced by FOXL2 overexpression was then followed by DNA chips (i.e. FOX...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-MEXP-985 | biostudies-arrayexpress
ProteomicsFOXL2 interaction with different binding partners regulates the dynamics of granulosa cell differentiation across ovarian development
FOXL2 is a transcription factor essential for female fertility, expressed in somatic cells of the ovary, notably granulosa cells. In the mouse, Foxl2 deletion leads to partial sex reversal postnatally. However, deletion of the gene in 8-week-old females leads to granulosa to Sertoli cell transdiffer...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-25 | PXD043951 | Pride
Ovary Chip-sicap Foxl2 
TranscriptomicsTranscription profiling of mouse ovaries lacking Foxl2, Wnt4 or Kit and wild type ovaries and testes
Comparison of Foxl2-null ovaries to wildtype ovaries, ovaries lacking Wnt4 or Kit, or testes, throughout mouse development. The goal of this study was to identify early Foxl2 target genes as well as other ovarian, anti-testis genes that may act independently of Foxl2. Experiment Overall Design: We s...
ORGANISM(S): Mus musculus 
2009-07-05 | E-GEOD-12905 | biostudies-arrayexpress
ProteomicsIdentification of protein co-localized with Foxl2 on chromatin
Foxl2 is a forkhead transcription factor essential for proper reproductive function in females. It is expressed in the somatic cell population of the gonad (granulosa cells) which forms the follicles of the ovary, the structures responsible for embedding and nurturing the oocytes during their develo...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD024439 | Pride
Chip-sicap Foxl2 Trim28 
TranscriptomicsTranscription profiling of mouse KK1 granulosa cells transfected with Foxl2-VP16 and Foxl2-MAD
The Foxl2 transcription factor is required for ovarian function during follicular development. Our approach to begin to understand Foxl2 function is through the identification of Foxl2 regulated genes in the ovary. Transiently transfected KK1 mouse granulosa cells were used to identify genes that a...
ORGANISM(S): Mus musculus 
2009-11-15 | E-GEOD-18891 | biostudies-arrayexpress
ProteomicsCRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
FOXL2 is a transcription factor that plays a key role in sex determination, ovary development and maintenance. Mutations related to this gene have been described in syndromes involving premature ovarian failure and granulosa cell tumors. This kind of rare cancer (less than 5% of diagnosed ovarian ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-15 | PXD053682 | Pride
Tmt Rare cancer Crispr Granulosa cell tumor Proteomics Foxl2 
TranscriptomicsGene knockdown and overexpression of 402C>G FOXL2 in COV434 and KGN cells
Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all GCTs examined. This investigation aims to identify the pat...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-39890 | biostudies-arrayexpress
ProteomicsModification of the transcription factor FOXL2 at serines 101 and 107 disables DNA binding, leads to nucleolar relocalization, and rewires granulosa-cell programs
FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely understood. Here, we show that protein kinase C phosphorylates FOXL2 in vitro. Two of the four phosphorylation sites, nota...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD076161 | Pride
Interactome Nucleolus Foxl2 phosphorylation Protein kinase c Transcriptome 
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