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TranscriptomicsTRIM28 is essential for erythroblast differentiation in the mouse
We discovered that Trim28 genetic loss in the adult mouse leads to defective immature erythropoiesis in the bone marrow and consequently to anemia.We further found that TRIM28 controls erythropoiesis in a cell-autonomous manner by inducibly deleting Trim28 exclusively in hematopoietic cells. Finally...
ORGANISM(S): Mus musculus 
2013-10-04 | E-GEOD-49843 | biostudies-arrayexpress
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
ProteomicsDDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation
DDX39B interacted with E3 ubiquitin ligase TRIM28 and underwent TRIM28-mediated K63-linked ubiquitination at Lys241, Lys384, and Lys398, leading to DDX39B protein stabilization and upregulation.
ORGANISM(S): Homo Sapiens 
PXD064812 |
TranscriptomicsRNA-seq of gonadal adipose tissue from male and female Trim28-WT and Trim28 adipose specific KO mice
Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. We set out to determine if adipose specific deletion of Trim28 led to changes in adipose ti...
ORGANISM(S): Mus musculus 
2020-11-25 | E-MTAB-9809 | biostudies-arrayexpress
GenomicsTRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
TRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
PRJNA1255479 | ENA
GenomicsChIP-seq of ADNP and TRIM28 in the U2OS cell line (Human Bone Osteosarcoma Epithelial Cells)
In order to investigate the functions of the zinc finger transcription regulator ZMYM2 and the different types of ZMYM2 binding complex with TRIM28 or ADNP, we generated the ChIP-seq data of ADNP or TRIM28 in U2OS cells.
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12292 | biostudies-arrayexpress
ProteomicsMarch5-mediated Trim28 degradation preserves islet β-cell function in mice
Insulin deficiency from β-cell dysfunction underpins both type 1 and type 2 diabetes. However, the regulatory pathways underlying β-cell function remain incompletely understood. Here, we identify that March5 and Trim28 as key modulators of β-cell function. March5 is downregulated and Trim28 upregula...
ORGANISM(S): Homo sapiens (Human) 
2025-07-24 | PXD066332 | Pride
Islet transplantation Mafa Kindlin-2 Insulin secretion Glucose intolerance 
GenomicsTRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
TRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
PRJNA1255163 | ENA
GenomicsTRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
TRIM28 is a key cardiomyocyte ferroptosis suppressor via TRIM28-IRP2-TFR1 signaling
PRJNA1255120 | ENA
TranscriptomicsRNA-seq of the U2OS cell line (Human Bone Osteosarcoma Epithelial Cells) treated with ZMYM2, TRIM28 or ADNP knock down against the control conditions.
In order to investigate the functions of the zinc finger transcription regulator ZMYM2 and the different types of ZMYM2 binding complex with TRIM28 or ADNP, we generated the RNA-seq data with ZMYM2, TRIM28 or ADNP siRNA in U2OS cells and the control cases with siNT in U2OS cells as well.
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12291 | biostudies-arrayexpress
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