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TranscriptomicsVL30 retro-transposons are TRIM24-repressed enhancers that generate non-coding RNA to regulate gene expression in mouse hepatocytes.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39853 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and jasmonate deficient mutant aos Arabidopsis plants in control conditions
comparison of the transcriptome of Columbia WT and the jasmonate deficient mutant aos (allene oxide synthase)in control conditions.
ORGANISM(S): Arabidopsis thaliana 
2008-02-01 | E-ATMX-36 | biostudies-arrayexpress
TranscriptomicsModulation of atherogenic lipidome
Objective: Although relationships between smoking and cardiovascular diseases (CVD), and CVD and lipids are established, direct impact of cigarette smoke (CS) on lipidomes remains elusive. We investigated the effect of 6 month smoke exposure on a well-established mouse model for human atherogenesis,...
ORGANISM(S): Mus musculus 
2013-10-03 | E-MTAB-1195 | biostudies-arrayexpress
GenomicsVL30 retro-transposons are TRIM24-repressed enhancers that generate non-coding RNA to regulate gene expression in mouse hepatocytes. [ChIP-Seq]
TRIM24 and TRIM33 interact to form a corepressor complex that suppresses murine hepatocellular carcinoma (HCC). TRIM24 and TRIM33 cooperatively repress retinoic acid receptor dependent activity of VL30 retro-transposons in hepatocytes in vivo. In TRIM24 knockout hepatocytes, VL30 long terminal repea...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39852 | biostudies-arrayexpress
TranscriptomicsChromatin dynamics and genome-wide profiling of repetitive elements during early mammalian embryogenesis.
We have used repetitive elements, including retrotransposons, as model loci to address how and when heterochromatin forms during development. High throughput RNA-sequencing using a Nano-CAGE protocol throughout early embryogenesis revealed that the expression of repetitive elements is abundant in...
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-39849 | biostudies-arrayexpress
GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
TranscriptomicsIGR_MACROPHAGE_MOUSE_MUTATION_CEA_PHR
Macrophage activation during the innate immune response is tightly regulated to prevent tissue damage while activating the defense to cellular attack. Using a mouse model where Trim33 is specifically deleted in mature myeloid cells, we show that TRIM33 is essential for two aspects of the inflammator...
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-1441 | biostudies-arrayexpress
MetabolomicsMTBLS12814: Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies

Background

Regular physical activity is known to benefit health but the long-term effects of specific exercise training on human metabolism remain incompletely described. In this study, we comprehensively characterized the blood metabolomes of male athletes with distinct exercise-adapted me...

2026-03-13 | MTBLS12814 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
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