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TranscriptomicsPOU4F1 is associated with t(8;21) AML and contributes directly to its unique transcriptional signature
POU4F1 is associated with t(8;21) acute myeloid leukemia (AML) and contributes directly to its unique transcriptional signature To identify targets of POU4F1, we performed gene expression profiling, comparing Pou4f1+/+ or Pou4f1-/- fetal liver cells to cells overexpressing POU4F1 and identified 140 ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-19997 | biostudies-arrayexpress
TranscriptomicsThe impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells
The extent to which differences in germ line DNA copy number contribute to natural phenotypic variation is unknown. We analyzed the copy number content of the mouse genome to a sub-10 kb resolution. We identified over 1,300 copy number variant regions (CNVRs), most of which are < 10 kb in length, ar...
ORGANISM(S): Mus musculus 
2009-03-08 | E-GEOD-10656 | biostudies-arrayexpress
UnknownPOU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
Not available
S-EPMC2868953 | biostudies-literature
UnknownIntegrated genomics of susceptibility to alkylator-induced leukemia in mice.
Not available
S-EPMC3018144 | biostudies-literature
UnknownFunctions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.
Not available
S-EPMC5507214 | biostudies-literature
UnknownStem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.
Not available
S-EPMC524043 | biostudies-literature
UnknownSensitivity to ATR-CHK1 pathway inhibition in AML/MDS is enhanced by <i>SRSF2</i> mutations and reduced by RUNX1 loss.
Not available
S-EPMC12632562 | biostudies-literature
UnknownU2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.
Not available
S-EPMC8553566 | biostudies-literature
UnknownRole of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Not available
S-EPMC4403236 | biostudies-literature
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
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