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TranscriptomicsThe impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells
The extent to which differences in germ line DNA copy number contribute to natural phenotypic variation is unknown. We analyzed the copy number content of the mouse genome to a sub-10 kb resolution. We identified over 1,300 copy number variant regions (CNVRs), most of which are < 10 kb in length, ar...
ORGANISM(S): Mus musculus 
2009-03-08 | E-GEOD-10656 | biostudies-arrayexpress
TranscriptomicsPOU4F1 is associated with t(8;21) AML and contributes directly to its unique transcriptional signature
POU4F1 is associated with t(8;21) acute myeloid leukemia (AML) and contributes directly to its unique transcriptional signature To identify targets of POU4F1, we performed gene expression profiling, comparing Pou4f1+/+ or Pou4f1-/- fetal liver cells to cells overexpressing POU4F1 and identified 140 ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-19997 | biostudies-arrayexpress
TranscriptomicswuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
Copy number variants (CNVs) are currently defined as genomic sequences that are polymorphic in copy number and range in length from 1,000 to several million base pairs. Among current array-based CNV detection platforms, long-oligonucleotide arrays promise the highest resolution. However, the perfo...
ORGANISM(S): Mus musculus 
2008-03-11 | E-GEOD-10511 | biostudies-arrayexpress
TranscriptomicsA high resolution map of segmental DNA copy number variation in the mouse genome
Submicroscopic (< 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. CNVs have been detected in diverse species, including mice and humans. Published...
ORGANISM(S): Mus musculus 
2006-11-20 | E-GEOD-5805 | biostudies-arrayexpress
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
GenomicsWhole-Genome Sequencing of Acute Myeloid Leukemia

We used massively parallel sequencing technology to sequence the genomic DNA of tumor cells (leukemic bone marrow) and normal cells (skin biopsy) obtained from patients with Acute Myeloid Leukemia (AML). Patients had either de novo AML (AML with no prior diagnosis of a hematologic disease or expo...

phs000159.v4.p2 | EGA
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