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TranscriptomicsChoriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD. Ten ...
ORGANISM(S): Macaca nemestrina 
2013-04-23 | E-GEOD-39029 | biostudies-arrayexpress
TranscriptomicsLarge-scale downregulation of cytokeratins in amniotic epithelium after Group B Streptococcus choriodecidual infection in Macaca nemestrina: a pathway to PPROM
Early events leading to intrauterine infection remain poorly defined, but may hold the key to a therapeutic intervention for preterm delivery. To determine early molecular pathways associated with membrane weakening that may progress to preterm premature rupture of membranes (PPROM), we examined th...
ORGANISM(S): Macaca nemestrina 
2014-11-18 | E-GEOD-46290 | biostudies-arrayexpress
TranscriptomicsIntra-amniotic Balloon Inflation Induces an Inflammatory “Pulse” and Labor in Nonhuman Primates
Uterine stretch is thought to induce preterm labor in women with twin and higher order pregnancies, but the pathophysiology remains unclear. We investigated the pathogenesis of stretch-induced preterm birth for the first time in a pregnant nonhuman primate model. Eleven chronically catheterized preg...
ORGANISM(S): Macaca nemestrina 
2015-09-11 | E-GEOD-63274 | biostudies-arrayexpress
TranscriptomicsmiR-155-5p regulates immune cell recruitment to the fetal lung after choriodecidual Group B Streptococcal infection
Mechanisms underlying in utero fetal lung injury remain poorly defined, and a greater understanding of pathways regulating these processes may lead to novel therapies that prevent lung injury before birth. MicroRNAs (miRNAs) are small non-coding, endogenous RNAs that regulate gene expression and hav...
ORGANISM(S): Macaca nemestrina 
2015-08-05 | E-GEOD-60628 | biostudies-arrayexpress
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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