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TranscriptomicsGene regulation in brain, eye and heart of sighted C3H mice
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the...
ORGANISM(S): Mus musculus 
2010-05-23 | E-GEOD-7855 | biostudies-arrayexpress
TranscriptomicsEyeless: Pitx3 mutant mouse line, Expression profiling of liver
A new mouse mutant arose spontaneously at the 5th inbred generation in a congenic C3H/He line. Since the mice suffered from anophthalmia or microphthalmia, we referred to this new mutant as eyeless (provisional gene symbol: eyl). The mutation follows an autosomal recessive pattern of inheritance and...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15336 | biostudies-arrayexpress
TranscriptomicsMultiple functions for Eya3 in mammalian organism
The important function of Eya (eyes absent) in eye development of D.melanogaster is well known, the function of its mammalian orthologs Eya1-4 is only partially understood. Yet, no phenotype for Eya2 and Eya3 in humans or mouse have been described. In our study we analysed new Eya-deficient mouse m...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-9999 | biostudies-arrayexpress
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