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GenomicsPeripheral blood mononuclear cells HELP-tagging cytosine methylation data (Albert Einstein College of Medicine)
Obesity-associated asthma is recognized as a distinct entity with non-atopic T-helper 1 polarized systemic inflammation. DNA methylation is linked with T helper cell maturation and is associated with inflammatory patterns in asthma and obesity. However, it is unknown whether pathologic dysregulation...
ORGANISM(S): Homo sapiens 
2014-04-14 | E-GEOD-43705 | biostudies-arrayexpress
GenomicsHuman embryonic stem cells HELP-tagging cytosine methylation data (Albert Einstein College of Medicine)
Background: To perform epigenome-wide association studies in human disease, assays need to be comprehensive and quantitative while remaining cost-effective. We explored how the strengths of prior tag-based cytosine methylation assays based on massively-parallel sequencing can be maximised analytica...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19937 | biostudies-arrayexpress
GenomicsHuman cervical cells HELP-tagging cytosine methylation data
We pursued the hypothesis that epigenetic regulators of transcription are involved in both the development and the progression of HPV-associated CIN. Using HELP-tagging, we performed the most comprehensive study to date of DNA methylation in HPV-associated cervical neoplasia, testing ~2 million loc...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-76986 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in normal and IUGR pancreatic islets
Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress
TranscriptomicsBCL6 ChIP on chip using a Nimblegen custom tiling array
To determine whether BCL6 binds to the certain locus we performed genomic localization studies by chromatin immunoprecipitations (ChIP) using a densely tiled custom oligonucleotide microarray covering the genomic loci of different genes. Keywords: ChIP-chip, Transcription Factor localization The ex...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-7673 | biostudies-arrayexpress
TranscriptomicsEpigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
The increase in atopic diseases has occurred in such a short period of time that it becomes difficult to be attributed only to genetic factors, which usually need more prolonged time periods to manifest. In this setting during the last decade, the science of epigenetics has increasingly developed of...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-26080 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma
In this study we present the first genome-wide expression profiling of peripheral B cells by massive parallel RNA sequencing in patients with allergic asthma validating the discovery potential of this approach in allergy. RNA-seq was used to asses expression differences in B CD19 Lymphocytes from ho...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-52742 | biostudies-arrayexpress
TranscriptomicsAnalysis of DNA methylation changes in normal human hematopoietic stem and progenitor cells
DNA methylation analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using HELP arrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in ...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52151 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Chronic kidney disease
Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine meth...
ORGANISM(S): Homo sapiens 
2013-07-18 | E-GEOD-48944 | biostudies-arrayexpress
TranscriptomicsAnalysis of RNA expression changes in normal human hematopoietic stem and progenitor cells
RNA expression analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using microarrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in R...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52150 | biostudies-arrayexpress
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