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ProteomicsThe Greatwall kinase safeguards the genome integrity by balancing the kinome activity in mitosis.
Mastl is commonly overexpressed in cancer, appearing as an alternative therapeutic anticancer target. Loss of Mastl induces multiple chromosomal mitotic errors that lead to the accumulation of micronuclei and multilobulated cells with polyploidy. Our detailed analyses display that loss of Mastl quic...
ORGANISM(S): Mus Musculus (mouse) 
2020-10-15 | PXD019297 | JPOST Repository
ProteomicsBalance between B55alpha and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
The Greatwall kinase is a key cell cycle regulator responsible for the timely inactivation of PP2A-B55 phosphatases and consequential stabilisation of critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understandin...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD059047 | Pride
Greatwall kinase Phosphoproteome Mitosis Pp2a Cell cycle B55alpha 
ProteomicsGreatwall kinase regulates SAC by controlling phosphorylation and activity of MPS1
The Greatwall/Mastl kinase is an essential gene, which regulates the phosphatase activity that counteracts the phosphorylation of Cdk1 substrates. Although Mastl-/- MEFs can enter mitosis, they are unable to complete mitosis due to chromosome segregation defects. Here, we show that Mastl is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004882 | Pride
Greatwall kinase/mastl/cyclin-dependent kinase/knockout mice/cdk1/mps1/sac 
ProteomicsThe MAST kinase KIN-4 provides the Greatwall activity in C. elegans
Mitotic entry is triggered by the Cyclin B-Cdk1 kinase, which phosphorylates numer-ous substrates. The accumulation of these phosphorylated substrates relies on inhib-iting the opposing PP2A-B55 phosphatase. With its asynchronous cell divisions, the C. elegans embryo is an attractive model for disse...
ORGANISM(S): Caenorhabditis elegans 
2025-05-07 | PXD054396 | Pride
Cell cycle Phosphatase C. elegans Development Kinase 
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
UnknownRegulation of Greatwall kinase during Xenopus oocyte maturation.
Not available
S-EPMC3128519 | biostudies-literature
UnknownRoles of Greatwall kinase in the regulation of cdc25 phosphatase.
Not available
S-EPMC2291418 | biostudies-literature
UnknownLoss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.
Not available
S-EPMC5025047 | biostudies-literature
UnknownThe MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans.
Not available
S-EPMC11961639 | biostudies-literature
UnknownCyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B.
Not available
S-EPMC7265243 | biostudies-literature
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