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TranscriptomicsGene expression data in control (shCtrl) and B55alpha-silenced (shB55a KD) HUVECs
Analysis of shRNA mediated KD of B55alpha in densely seeded HUVECs
ORGANISM(S): Homo sapiens 
2020-05-08 | E-MTAB-9002 | biostudies-arrayexpress
GenomicsGene expression data in control (shCtrl) and B55alpha-silenced (shB55a KD) HUVECs
Gene expression data in control (shCtrl) and B55alpha-silenced (shB55a KD) HUVECs
PRJEB38049 | ENA
UnknownLive-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
Not available
S-EPMC3839080 | biostudies-literature
ProteomicsBalance between B55alpha and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
The Greatwall kinase is a key cell cycle regulator responsible for the timely inactivation of PP2A-B55 phosphatases and consequential stabilisation of critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understandin...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD059047 | Pride
Greatwall kinase Phosphoproteome Mitosis Pp2a Cell cycle B55alpha 
ProteomicsProteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione
Vasculogenic therapies have been investigated for the treatment of peripheral artery disease (PAD) with very limited success in clinical trials. The isoform PP2A (protein phosphatase 2)/B55alpha inhibits the activity of the prolyl hydroxylase 2 (PHD2) and activates the hypoxia inducing factor-1alpha...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-03 | PXD050360 | Pride
Vascular tissue Critical limb ischemia 
UnknownPP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.
Not available
S-EPMC10404246 | biostudies-literature
ProteomicsPP2A/B55a substrate recruitment as defined by the retinoblastoma-related protein p107
Protein phosphorylation is a reversible post-translation modification essential in cell signaling. This study addresses a long-standing question as to how the most abundant serine/threonine Protein Phosphatase 2 (PP2A) holoenzyme, PP2A/B55a, specifically recognizes substrates and presents them to th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088106 | MassIVE
TranscriptomicsGenome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations
This SuperSeries is composed of the following subset Series: GSE39380: Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) GSE39381: Genome-wide analysis of primary plasma cell leukemia identifies recu...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-39383 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the thebiological risk factors associated with PCa disparities observed in AA and EA patients, we performed microRNA profiling using Agilent Human miRNA a...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64318 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the biological factors accounting for the PCa disparities observed in AA and EA patients, we performed gene profiling analysis using Affymetrix human exon...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64331 | biostudies-arrayexpress
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