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TranscriptomicsFGF2 stimulation experiment with CD1 mouse embryonic fibroblasts
Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. as detailed for the individual samples
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5435 | biostudies-arrayexpress
TranscriptomicsFGF2 stimulation experiment with NMRI mouse embryonic fibroblasts
Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. as detailed for the individual samples
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5436 | biostudies-arrayexpress
TranscriptomicsGeneration of parthenogenetic iPS cells from parthenogenetic neural stem cell
In pluripotential reprogramming, a pluripotent state is established within somatic cells. In this study, we have generated induced pluripotent stem (iPS) cells from bi-maternal (uniparental) parthenogenetic neural stem cells (pNSCs) by transduction with four (Oct4, Klf4, Sox2, and c-Myc) or two (Oct...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-15561 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles of mouse ESCs, disease-specific iPSCs, and gene-corrected iPSCs
The use of patient-derived induced pluripotent stem (iPS) cells as treatment for genetic diseases entails genetic repair or transfer of genetic information as a prerequisite. We have chosen the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase deficiency; FAH(-/-) mice) as a paradigm...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21343 | biostudies-arrayexpress
TranscriptomicsIdentification of genes specific to mouse primordial germ cells through dynamic global gene expression
The molecular mechanisms underlying the commitment of cells to the germ cell lineage and the subsequent formation of germ cells during mammalian development remain poorly understood due to an inability to obtain sufficient amounts of cellular materials to conduct thorough in-vitro analyses. Although...
ORGANISM(S): Mus musculus 
2010-11-16 | E-GEOD-23322 | biostudies-arrayexpress
TranscriptomicsInvestigation of signaling requirements underlying cardiac induction of human pluripotent stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-67180 | biostudies-arrayexpress
TranscriptomicsLong-term maintenance time-course of cardiomyocytes differentiated from human pluripotent stem cells and comparison to human heart
Analysis of culture-induced changes in cardiomyocytes (CMs) differentiated from human pluripotent stem cells (hPSCs) over a time-period of 8 weeks, and comparison of these samples to human atrial and ventricular tissue Total RNA isolated from differentiated in-vitro samples at the indicated time-poi...
ORGANISM(S): Homo sapiens 
2014-12-16 | E-GEOD-64189 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Human Neural Stem Cells by OCT4
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells....
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15355 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Epiblast Stem Cells
Embryonic stem cells (ESCs), which are derived from the primitive ectoderm of pre-implantation blastocysts, are pluripotent cells and can thus contribute to the formation of all somatic cell lineages in chimeric animals. Similarly, epiblast stem cells (EpiSCs), which are derived from epiblast tissu...
ORGANISM(S): Mus musculus 
2010-12-08 | E-GEOD-21516 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors
Recent advances in the stem cell biology have revealed that cell type-specific transcription factors could reset the somatic memory and induce direct reprogramming into specific cellular identities. The induction of pluripotency in terminally differentiated cells has been a major achievement in the ...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-30500 | biostudies-arrayexpress
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