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TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia I.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76741 | biostudies-arrayexpress
TranscriptomicsmicroRNAs expression profile in Myotonic Dystrophy type-2 (DM2) patients
Myotonic Dystrophy Type-2 (DM2) is an autosomal dominant disease caused by the expansion of a CCTG tetraplet repeat. It is a multisystemic disorder, affecting skeletal muscles, the heart, the eye, the central nervous system and the endocrine system The expression of 365 miRNAs was measured in the mu...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-37794 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure
Increased morbidity and mortality associated with post-ischemic heart failure (HF) in diabetic patients underscore the need for a better understanding of the underlying molecular events. Indeed, effective HF therapy in diabetic patients requires a complex strategy encompassing the development of imp...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-26887 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [U266 human myeloma cell line]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66292 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [Patient samples]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66291 | biostudies-arrayexpress
ProteomicsStandardization of mitochondrial proteomics v2 NP
Comparison of the extraction performances of three different mitochondria enrichment protocols (differential centrifugation, sucrose gradient, a commercial kit based on surfactants) on ten different cell lines. Samples were analysed on several instrumental platforms. Mitochondrial pellets were lysed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-14 | MSV000081329 | MassIVE
ProteomicsStandardization of mitochondrial proteomics
Comparison of the extraction performances of three different mitochondria enrichment protocols (differential centrifugation, sucrose gradient, a commercial kit based on surfactants) on ten different cell lines. Samples were analysed on several instrumental platforms. Mitochondrial pellets were lysed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-30 | MSV000081121 | MassIVE
TranscriptomicsARSD expression correlates with IgVH mutational status, ZAP-70 and disease progression in chronic lymphocytic leukemia
Several studies demonstrated IgVH mutation status and ZAP-70 expression as the most relevant prognostic markers in CLL, suggesting the separation of two patient subgroups: with good (MTZAP-70-) and poor prognosis (UMZAP-70+). We determined gene expression of B cells in 112 CLL patients divided into...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-28654 | biostudies-arrayexpress
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