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TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
UnknownAn atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.
Not available
S-EPMC2781534 | biostudies-literature
TranscriptomicsGW7647 and Rosiglitazone treated human differentiated adipocytes
Objective : This work aimed at characterizing PPARα involvement in metabolism regulation and at comparing PPARα and PPARγ roles in human white adipocytes. Research Design and Methods : Profiling of gene expression alterations was assessed with microarrays and RT-qPCR. Primary cultures of human adipo...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-15862 | biostudies-arrayexpress
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
Transcriptomicsler vs pop2-1: gaba over-accumulation effects-Transcriptomic analysis of pop2-1 mutant in Arabidopsis thaliana
au05-03_gaba - ler vs pop2-1: gaba over-accumulation effects - The analysis aims at identifying genes that are differentially regulated by the over-accumulation of GABA observed in the mutant pop2-1 in response to treatment with exogenous GABA and that may explain the singular phenotype of the mutan...
ORGANISM(S): Arabidopsis thaliana 
2009-04-11 | E-GEOD-11129 | biostudies-arrayexpress
TranscriptomicsmiRNA 135b regulation by Il1r1 during inflammation
RT-PCR analysis of inflammatory cytokines and receptors following Il1alpha treatment of pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression ...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43683 | biostudies-arrayexpress
TranscriptomicsmiRNA 135b regulation of inflammation
RT-PCR analysis of inflammatory cytokines and receptors in pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression profiling. This experiment ex...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43681 | biostudies-arrayexpress
TranscriptomicsInterlaboratory study to determine the reproducibility of toxicogenomics datasets
The application of toxicogenomics as a predictive tool for chemical risk assessment has been under evaluation by the toxicology community for more than a decade. However, toxicogenomics predominately remains a tool for investigative research rather than for regulatory risk assessment. In this study,...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-25936 | biostudies-arrayexpress
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 1
To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (50M-BM- ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45598 | biostudies-arrayexpress
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