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TranscriptomicsIntegrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines. DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-22208 | biostudies-arrayexpress
MetabolomicsThe influence of Pseudomonas aeruginosa infection on the airway metabolome
Pseudomonas aeruginosa is an environmentally resilient bacterium and an important cause of both acute and chronic infections in people with impaired natural barriers or immunological defences. Chronic respiratory infection with P. aeruginosa is a major cause of morbidity and mortality in people with...
2025-11-06 | MTBLS6052 | MetaboLights
TranscriptomicsChanges in transcription patterns in BoMac cells in response to PDD spirochetes
Papillomatous digital dermatitis (PDD) is a polymicrobial infection in soft tissue adjacent to the hoof and is the leading cause of lameness in dairy cattle. Treponema phagedenis-like (TPL) spirochetes are a constant feature of PDD lesions and are localized deep in infected tissue. Host-cell respon...
ORGANISM(S): Bos taurus 
2007-06-22 | E-GEOD-6702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse naive CD8+ T-cell differentiation during a primary immune response
Title: Gene Expression analysis of naive CD8+ T-cell differentiation during a primary immune response Description: C57BL/6 wild type mice are administered GK1.5 (depleting anti CD4 antibody) or isotope control by intraperitoneal injection at 3 and 1 day pre-infection, then every 36-48 hour...
ORGANISM(S): Mus musculus 
2005-09-29 | E-MIMR-38 | biostudies-arrayexpress
UnknownA Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.
Not available
S-EPMC11770632 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownCorrelation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non-Small Cell Lung or Colorectal Cancer.
Not available
S-EPMC8314138 | biostudies-literature
UnknownAdjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-stage follicular lymphoma.
Not available
S-EPMC11663783 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownDivergent mutational processes distinguish hypoxic and normoxic tumours.
Not available
S-EPMC7002770 | biostudies-literature
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