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GenomicsTransposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
We describe an assay for transposase-accessible chromatin using sequencing (ATAC-seq), based on direct in vitro transposition of sequencing adaptors into native chromatin, as a rapid and sensitive method for integrative epigenomic analysis. ATAC-seq captures open chromatin sites using a simple two-s...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-47753 | biostudies-arrayexpress
TranscriptomicsHigh-resolution nucleosome positioning from ATAC-seq chromatin accessibility data
We describe the NucleoATAC algorithm for high-resolution nucleosome positioning and occupancy determination using ATAC-seq. ATAC-seq was performed on Saccharomyces cerevisiae and Schizosaccaromyces pombe. Nucleosomes were called for both species as well as for the human GM12878 cell line using data ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-22 | E-GEOD-66386 | biostudies-arrayexpress
GenomicEpigenomics of Human CD8 T cell Differentiation and Aging

The efficacy of the adaptive immune response declines dramatically with age, but the cell-intrinsic mechanisms driving the changes characteristic of immune aging in humans remain poorly understood. One hallmark of immune aging is the loss of self-renewing naive cells and the accumulation of diffe...

phs001187 | dbGaP
UnknownAMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.
Not available
S-EPMC6626132 | biostudies-literature
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