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TranscriptomicsMembers of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family1, 2, but less is known about the role of other histone modifications in l...
ORGANISM(S): Caenorhabditis elegans 
2011-07-08 | E-GEOD-30505 | biostudies-arrayexpress
GenomicsIdentification of N6-adenine methylation in C. elegans DNA
In mammalian cells, DNA methylation on the 5th position of cytosine (5mC) plays an important role as an epigenetic mark. However, DNA methylation was considered to be absent in C. elegans because of the lack of detectable 5mC as well as homologs of the cytosine DNA methyltransferases. Here, using mu...
ORGANISM(S): Caenorhabditis elegans 
2015-05-05 | E-GEOD-66504 | biostudies-arrayexpress
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
ProteomicsRole of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium
The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that exists in both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity. While...
ORGANISM(S): Dictyostelium Discoideum Ax2 
PXD024225 | panorama
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