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TranscriptomicsTargeted RNA-seq (TempO-Seq) of human induced pluripotent stem cell (hiPSC)-derived hepatocyte like cells (HLCs) treated with Nitrofurantoin against control condition
We wanted to investigate the transcriptional effect of Nitrofurantoin, a known drug induced liver injury (DILI)-compound, on hiPSC-derived HLCs. The goal was to identify which srress response pathways and biological processes are activated or altered in HLCs following Nitrofurantoin exposure. The co...
ORGANISM(S): Homo sapiens 
2025-08-09 | E-MTAB-15398 | biostudies-arrayexpress
TranscriptomicsGene Regulation of Intestinal Porcine Epithelial Cells IPECM-bM-^@M-^QJ2 is Dependent on the Site of Deoxynivalenol Toxicological Action
Here we analysed different mechanisms of apical and basolateral deoxynivalenol (DON) toxicity reflected in the gene expression. We used the jejunum derived, polarized intestinal porcine epithelial cell line IPECM-bM-^@M-^QJ2 as an in vitro cell culture model. Luminal and blood stream DON intoxicatio...
ORGANISM(S): Sus scrofa 
2012-12-31 | E-GEOD-33246 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of human hepatocellular carcinoma cell line HepG2, primary human hepatocytes (PHHs) and human induced pluripotent stem cell derived hepatocyte like cells (HLCs) in untreated condition
We aimed to compare the baseline expression of liver function and metabolism-related genes across the three liver models. Liver in vitro models are commonly used to study liver biology, disease mechanisms, and drug metabolism. Understanding their baseline gene expression profiles is crucial for inte...
ORGANISM(S): Homo sapiens 
2025-08-09 | E-MTAB-15401 | biostudies-arrayexpress
TranscriptomicsIFNa and IL4 DCs stimulated with microbial components for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44719 | biostudies-arrayexpress
TranscriptomicsIFNa DCs and IL4 DCs exposed to H1N1, heat killed S. aureus, or heat killed S. enterica (HKSE) for 1h, 2h, 6h, 12h, or 24h
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44720 | biostudies-arrayexpress
TranscriptomicsIL4 DCs and monocytes stimulated by 13 human vaccines and LPS for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44721 | biostudies-arrayexpress
TranscriptomicsTranscriptional specialization of human dendritic cell subsets in response to microbial vaccines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44722 | biostudies-arrayexpress
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
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