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TranscriptomicsSequence discrimination study
The use of DNA microarrays to identify nucleotide variation is almost 20 years old. A variety of improvements in probe design and experimental conditions have brought this technology to the point that single-nucleotide differences can be efficiently detected in unmixed samples, although developing r...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-19319 | biostudies-arrayexpress
ProteomicsPost-transcriptional mechanisms modulate the consequences of adaptive copy number variation
Copy-number variants (CNVs) are large-scale amplifications or deletions of DNA that can drive rapid adaptive evolution and result in large-scale changes in gene expression. Whereas alterations in the copy number of one or more genes within a CNV can confer a selective advantage, other genes within a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-11-01 | PXD046587 | Pride
Long-term experimental evolution (ltee) Glutamine-limited growth media Copy-number variant (cnv) Saccharomyces cerevisiae Orbitrap 
TranscriptomicsDynamics of Nitrogen-regulated Gene Expression Reveals a Reciprocal Relationship between Cell Growth Rate and Nitrogen Catabolism
Cell growth rate is regulated in response to resource availability including the abundance, and molecular form, of essential nutrients. In the model eukaryotic cell, Saccharomyces cerevisiae (budding yeast), the molecular form of environmental nitrogen impacts both cell growth rate and mRNA express...
ORGANISM(S): Saccharomyces cerevisiae 
2014-05-05 | E-GEOD-57293 | biostudies-arrayexpress
TranscriptomicsThe Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
The experimental evolution of laboratory populations of microbes provides an opportunity to observe the evolutionary dynamics of adaptation in real time.Until very recently, however, such studies have been limited by our inability to systematically find mutations in evolved organisms.We overcome thi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-13435 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis thaliana root protoplast
BACKGROUND:Dynamic transcriptional regulation is critical for an organism's response to environmental signals and yet remains elusive to capture. Such transcriptional regulation is mediated by master transcription factors (TF) that control large gene regulatory networks. Recently, we described a dyn...
ORGANISM(S): Arabidopsis thaliana 
2016-02-08 | E-GEOD-69389 | biostudies-arrayexpress
TranscriptomicsMolecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments [aCGH]
One of the central goals of evolutionary biology is to explain and predict the molecular basis of adaptive evolution. We studied the evolution of genetic networks in Saccharomyces cerevisiae (budding yeast) populations propagated for more than 200 generations in different nitrogen-limiting condition...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-28 | E-GEOD-52696 | biostudies-arrayexpress
TranscriptomicsMolecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments [GE]
One of the central goals of evolutionary biology is to explain and predict the molecular basis of adaptive evolution. We studied the evolution of genetic networks in Saccharomyces cerevisiae (budding yeast) populations propagated for more than 200 generations in different nitrogen-limiting condition...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-28 | E-GEOD-52786 | biostudies-arrayexpress
UnknownCyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Not available
S-EPMC6402543 | biostudies-literature
UnknownIdentification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Not available
S-EPMC6407917 | biostudies-literature
Genomicsena-DATASET-irgb_cnr-12-01-2017-10:08:18:724-1 - samples
List of SNPs, and their frequencies, extracted from a low pass whole genome sequencing of 3,514 individuals.
EGAD00001003141 | EGA
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