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TranscriptomicsGene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis
Although corticosteroids remain a mainstay of therapy for UC, a meta-regression of cohort studies in acute severe ulcerative colitis (UC) showed that 29% of patients fail corticosteroid therapy and require escalation of medical management or colectomy. We aimed to determine whether genes expressed i...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-21231 | biostudies-arrayexpress
MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
UnknownThe NRP1 migraine risk variant shows evidence of association with menstrual migraine.
Not available
S-EPMC5906416 | biostudies-literature
TranscriptomicsmiR-155 regulates the ability of circulating cancer cells to colonize and establish metastasis
Abstract: Metastases are established through a complex multistep process by which tumor cells disseminate from the primary tumor and expand at distant sites. Traditionally, studies on metastasis have focused on proteins and protein-coding genes, but recently microRNAs (miRNAs) have achieved increasi...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37719 | biostudies-arrayexpress
UnknownSafety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study.
Not available
S-EPMC5557041 | biostudies-literature
UnknownClinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.
Not available
S-EPMC4843946 | biostudies-literature
GenomicsNIDDK IBD Genetics Consortium Crohn's Disease Genome-Wide Association Study

This dataset contains data from a genome-wide association study performed with 968 Inflammatory Bowel Disease (IBD) affected cases and 995 unrelated controls using the Illumina HumanHap300 Genotyping BeadChip. Cases were selected to have Crohn's disease with ileal involvement, and con...

phs000130.v1.p1 | EGA
UnknownLIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.
Not available
S-EPMC3008749 | biostudies-literature
UnknownImmune Checkpoint Inhibitor Therapy and Associations with Clonal Hematopoiesis.
Not available
S-EPMC11508050 | biostudies-literature
GenomicsNIDDK IBD Genetics Consortium Ulcerative Colitis Genome-Wide Association Study

This dataset contains data for 1,028 white, non-Hispanic, European ancestry individuals with ulcerative colitis who were included in a genome-wide association study published by Silverberg et al. (2009). These individuals were ascertained in North America and selected to have either left-sided ...

phs000345.v1.p1 | EGA
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