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UnknownDNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis.
Not available
S-EPMC4267653 | biostudies-literature
UnknownThe H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor.
Not available
S-EPMC5861437 | biostudies-literature
UnknownAn advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases.
Not available
S-EPMC7220381 | biostudies-literature
ProteomicsWhole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Our comprehensive model identifies condition-dependent and compartment-specific constraints that can explain metabolic strategies and protein expression profiles from growth rate optimization, providin a framework to understand metabolic adaptation in eukaryal cells.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-01-24 | PXD030003 | Pride
Genetic regulation Ms/ms Metabolic networks 
UnknownStructure and mechanism of antiphage retron Eco2.
Not available
S-EPMC12916289 | biostudies-literature
UnknownWhole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies.
Not available
S-EPMC8831649 | biostudies-literature
ProteomicsRetron Eco2 breaks tRNAs for antiphage defense
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here, we dissect the mechanism of Eco2, a minimal retron composed of a single reverse transcriptase–nuclease...
ORGANISM(S): Escherichia coli 
2026-02-23 | PXD067212 | Pride
Retron antiphage defense ribosomal protein s1 
ProteomicsRetron Eco2 breaks tRNAs for anti-phage defense
Retrons mediate bacterial anti-phage defense by reverse transcribing non-coding RNA into multicopy single-stranded DNA (msDNA). Our study reveals the unique trimeric nucleoprotein structure of Eco2, which solely relies on a single protein for defense, unlike most other retrons. This structure suppor...
ORGANISM(S): Escherichia coli 
2026-02-03 | PXD060313 | Pride
Retron Cryo-em Hdx-ms Anti-phage defense 
UnknownThe Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial.
Not available
S-EPMC5774109 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
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