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ProteomicsRetron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against bacteriophages
Retrons are toxin-antitoxin systems protecting bacteria against bacteriophages via abortive infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non-coding RNA (ncRNA)/multi-copy single-stranded DNA (msDNA) hybrid that neutralizes an uncharacterized toxic effector. Ye...
ORGANISM(S): Escherichia coli 
2024-05-23 | PXD044835 | Pride
Immune system Toxin-antitoxin systems Retron-eco1 Ribosyltransferase Bacterial antiphage defense system Reverse transcriptase Bacterial retrons Ec86 
ProteomicsRetron Eco2 breaks tRNAs for antiphage defense
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here, we dissect the mechanism of Eco2, a minimal retron composed of a single reverse transcriptase–nuclease...
ORGANISM(S): Escherichia coli 
2026-02-23 | PXD067212 | Pride
Retron antiphage defense ribosomal protein s1 
GenomicsViruses encode tRNA and anti-retron to evade bacterial immunity
Viruses encode tRNA and anti-retron to evade bacterial immunity
PRJNA1080571 | ENA
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Retrons are prokaryotic genetic elements involved in anti-phage defense and consist of a non-coding RNA, a reverse transcriptase (RT), and various effector proteins. Retron-Eco7 (previously known as Retron-Ec78) from Escherichia coli encodes two effector proteins (a PtuA ATPase and a PtuB nuclease) ...
ORGANISM(S): Escherichia coli str. K-12 substr. DH10B 
2025-10-23 | GSE293394 | GEO
GenomicsMapping of mutations that alleviate a retron-mediated phenotype in Salmonella
Mapping of mutations that alleviate a retron-mediated phenotype in Salmonella
PRJEB38324 | ENA
TranscriptomicsViruses encode tRNA and anti-retron to evade bacterial immunity
Retrons are bacterial genetic retroelements that encode reverse transcriptase capable of producing multicopy single-stranded DNA (msDNA) and function as antiphage defense systems. Phages employ several strategies to counter the host defense systems, but no mechanisms for evading retrons are known. H...
ORGANISM(S): Escherichia coli 
2025-06-01 | GSE259275 | GEO
GenomicsViruses encode tRNA and anti-retron to evade bacterial immunity [PrrC170]
Retrons are bacterial genetic retroelements that encode reverse transcriptase capable of producing multicopy single-stranded DNA (msDNA) and function as antiphage defense systems. Phages employ several strategies to counter the host defense systems, but no mechanisms for evading retrons are known. H...
ORGANISM(S): Escherichia coli 
2024-10-10 | GSE256078 | GEO
GenomicsViruses encode tRNA and anti-retron to evade bacterial immunity [Ec83]
Retrons are bacterial genetic retroelements that encode reverse transcriptase capable of producing multicopy single-stranded DNA (msDNA) and function as antiphage defense systems. Phages employ several strategies to counter the host defense systems, but no mechanisms for evading retrons are known. H...
ORGANISM(S): Escherichia coli 
2024-10-10 | GSE256077 | GEO
GenomicsViruses encode tRNA and anti-retron to evade bacterial immunity [Ec83]
Viruses encode tRNA and anti-retron to evade bacterial immunity [Ec83]
PRJNA1078004 | ENA
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Structural mechanism of the Retron-Eco7 anti-phage defense system
PRJNA1244356 | ENA
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