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ProteomicsRetron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against bacteriophages
Retrons are toxin-antitoxin systems protecting bacteria against bacteriophages via abortive infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non-coding RNA (ncRNA)/multi-copy single-stranded DNA (msDNA) hybrid that neutralizes an uncharacterized toxic effector. Ye...
ORGANISM(S): Escherichia coli 
2024-05-23 | PXD044835 | Pride
Immune system Toxin-antitoxin systems Retron-eco1 Ribosyltransferase Bacterial antiphage defense system Reverse transcriptase Bacterial retrons Ec86 
UnknownAn enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks.
Not available
S-EPMC11326160 | biostudies-literature
UnknownAn enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks.
Not available
S-EPMC12311787 | biostudies-literature
UnknownHigh throughput variant libraries and machine learning yield design rules for retron gene editors.
Not available
S-EPMC11754653 | biostudies-literature
UnknownHigh Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors.
Not available
S-EPMC11257497 | biostudies-literature
Genomics
High-Throughput Libraries and Machine Learning-Guided Optimization of Retron Editrons
PRJNA1121319 | ENA
UnknownCryoEM dataset of Retron-Eco1 E106A filaments
Not available
EMPIAR-12796 | biostudies-other
Genomics
Retron-mediated adenine and cytosine base editing for Targeted Hypermutation in Escherichia coli
PRJNA1537922 | ENA
UnknownCryoEM dataset of Retron-Eco1 WT filaments in the presence of NAD+
Not available
EMPIAR-12793 | biostudies-other
UnknownCryoEM dataset of Retron-Eco1 "-1-turn" mutant filaments in the presence of NAD+
Not available
EMPIAR-12799 | biostudies-other
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