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TranscriptomicsRegulatory T cell-mediated resolution of lung injury: Identification of potential target genes via expression profiling
We examined early and late gene expression changes using the IT LPS model of Acute Lung Injury (ALI). In this model, injury peaks at day 4 and is almost completely resolved by day 10 in wild type (WT) C57BL/6 mice. In contrast to the pattern in WT mice, lymphocyte-deficient Rag-1 -/- mice exhibit ...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-17355 | biostudies-arrayexpress
TranscriptomicsChronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice
Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We ex...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21409 | biostudies-arrayexpress
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