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TranscriptomicsGenome-wide analysis of mouse intestinal adenoma identifies early steps in the formation of cancer-specific DNA methylation patterns
Aberrant CpG methylation is a universal trait of cancer cell genomes and can result in epigenetic modulation of gene activity; however, at which stages tumour-specific epigenetic patterns arise is unknown. Here, we analyse the methylome of APCM in mouse intestinal adenoma as a model of intestinal ca...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-38983 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of transcription factor Dpf3 in mouse myoblast cells (C2C12) to identify genome wide binding sites
The aim of the experiment was to identify genome wide binding sites for the transcription factor Dpf3 by using Chromatin Immunoprecipitation followed by microarray analysis (ChIP-chip) in C2C12 cells.
ORGANISM(S): Mus musculus 
2008-08-01 | E-TABM-362 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large coho...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
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