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GenomicsGenome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large coho...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
TranscriptomicsRNA-seq of isolated tumor cells from high grade serous ovarian cancer (HGSOC) patients
Tumor cells were isolated from solid tumors or ascites from HGSOC patients and enriched for EpCAM expression by antibody magnetic beads (affinity)-based methods and large RNAs (> 200 nt) sequenced (50 bp paired ends) after rRNA depletion (RiboZero). Expression differences between patients with milia...
ORGANISM(S): Homo sapiens 
2020-01-01 | E-MTAB-7674 | biostudies-arrayexpress
TranscriptomicsCAR-adapted PIK3CD base editing enhances T cell anti-tumor potency
Insufficient functional T cell persistence impedes therapeutic success of chimeric antigen receptor (“CAR”) therapies. Here, we performed a CAR-adapted base editing screen of PIK3CD, a key regulator of T cell function, metabolism, and fate. We identified point mutations that beneficially modulate CA...
ORGANISM(S): Homo sapiens 
2025-11-06 | E-MTAB-15749 | biostudies-arrayexpress
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