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UnknownTCR-independent CD137 (4-1BB) signaling promotes CD8<sup>+</sup>-exhausted T cell proliferation and terminal differentiation.
Not available
S-EPMC10649891 | biostudies-literature
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - angular gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020517 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
UnknownClinical and neuropathological associations of plasma Aβ<sub>42</sub>/Aβ<sub>40</sub>, p-tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders.
Not available
S-EPMC11780117 | biostudies-literature
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020538 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
UnknowniPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
Not available
S-EPMC11866097 | biostudies-literature
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus (sarkosyl soluble)
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020717 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
UnknownNeuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study.
Not available
S-EPMC7847437 | biostudies-literature
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus (sarkosyl soluble)
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088409 | MassIVE
Unknown18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.
Not available
S-EPMC7719031 | biostudies-literature
ProteomicsPRM and DDA Data for IR5 WIW and WIW Nanobodies
Journal Article: Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils
ORGANISM(S): Synthetic Antibodies Nanobodies 
2023-06-16 | MSV000092197 | MassIVE
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