Sort   by:  
 Page size 
ProteomicsStructural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model
Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compa...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-05-12 | PXD035833 | Pride
Proteomics Brain Growth hormone receptor deficiency Pig Animal model 
TranscriptomicsExpression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes
We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone (GH)-deficient state. Using microarray profiles, comparison between h-hepatocytes from h-GH-treated and untreated mice identified 14 GH-up-regulated and four GH-down-regul...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26224 | biostudies-arrayexpress
TranscriptomicsSex-specific early growth hormone response genes in rat liver (Rattus norvegicus)
A series of two color gene expression profiles obtained using Agilent 44K expression microarrays was used to examine sex-dependent and growth hormone-dependent differences in gene expression in rat liver. This series is comprised of pools of RNA prepared from untreated male and female rat liver, hy...
ORGANISM(S): Rattus norvegicus 
2008-05-24 | E-GEOD-11529 | biostudies-arrayexpress
ProteomicsBiomarkers of favorable immune capacity in growth hormone receptor knockout pig model
Laron Syndrome (LS) is a rare hereditary disease in humans caused by a mutation in the growth hormone receptor gene which leads to high levels of circulating GH [1]. The disease is characterized by short statue, obesity, transient hypoglycemia during youth and low incidences of cancer and diabetes [...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-20 | PXD038772 | Pride
Quantitative label-free lc-ms/ms  laron syndrome  ghr-ko  porcine model  immune function 
ProteomicsProteomic changes of the liver in the absence of growth hormone (GH) actions
The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A systematic multi-omics analysis of GH actions in the liver has not been performed. GH receptor (GHR) deficiency is a unique m...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-03-30 | PXD017671 | Pride
Liver  growth hormone  laron syndrome  pig model  proteomics 
TranscriptomicsTranscription profiling of estrogen receptor positive breast cancer cell lines after long term estrogen deprivation
Hyperactivation of phosphatidylinositol-3 kinase (PI3K) promotes escape from hormone dependence in estrogen receptor-positive breast cancer. A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. We used gene expression microarrays to identify genes...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19639 | biostudies-arrayexpress
TranscriptomicsBreast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program
A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-22533 | biostudies-arrayexpress
TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
UnknownStructural basis for activation of the growth hormone-releasing hormone receptor.
Not available
S-EPMC7567103 | biostudies-literature
TranscriptomicsReal-time quantitative PCR analysis of hormone-receptor-negative primary breast tumors
Total RNA was extracted from FFPE samples of 139 chemotherapy-naïve hormone-receptor-negative breast cancers pooled from three sample sources and assayed for the expression of 21 genes within two previously reported microarray-derived prognostic signatures in 6 RT-PCR multiplexes. RT-PCR gene expre...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51630 | biostudies-arrayexpress
Sort   by:  
 Page size