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UnknownDevelopment of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum.
Not available
S-EPMC10465345 | biostudies-literature
TranscriptomicsThe role of Ternary Complex factors in T-cell Positive Selection
Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there i...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21546 | biostudies-arrayexpress
UnknownGrowth-coupled selection of 5-aminolevulinic acid synthetase mutants for 5-aminolevulinic acid biosynthesis in <i>Corynebacterium glutamicum</i>.
Not available
S-EPMC12746484 | biostudies-literature
UnknownGrowth-Coupled Evolutionary Pressure Improving Epimerases for D-Allulose Biosynthesis Using a Biosensor-Assisted In Vivo Selection Platform.
Not available
S-EPMC11005681 | biostudies-literature
TranscriptomicsTranscription profiling of S. cerevisiae after prolonged selection in aerobic, glucose-limited chemostat cultures
Prolonged cultivation of Saccharomyces cerevisiae in aerobic, glucose-limited chemostat cultures (dilution rate, 0·10 h–1) resulted in a progressive decrease of the residual glucose concentration (from 20 to 8 mg l–1 after 200 generations). This increase in the affinity for glucose was accompan...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8898 | biostudies-arrayexpress
UnknownGrowth-coupled continuous directed evolution by MutaT7 enables efficient and automated enzyme engineering.
Not available
S-EPMC12016552 | biostudies-literature
ProteomicsExpanding the scope of redox balance growth coupling techniques with a carbon co-feeding strategy
Metabolic engineering to produce molecules not naturally synthesized by the host often requires directed evolution to improve pathway enzyme performance. Growth-coupled selection can dramatically increase directed-evolution throughput, and manipulation of redox balance has proven effective for tying...
ORGANISM(S): Escherichia coli 
2026-10-15 | PXD075294 | Pride
Hmg-coa reductase (hmgr) Cofactor specificity Directed evolution 3-hydroxybutyrate Growth-coupled selection Redox balance Jbei Mevalonate pathway 
UnknownA growth-coupled progesterone-responsive biosensor for high-throughput microfluidic screening in <i>Saccharomyces cerevisiae</i>.
Not available
S-EPMC12805089 | biostudies-literature
TranscriptomicsTranscription profiling time series of thymocytes from HNT-TCR transgenic mice injected with HA peptide to induce thymic negative selection
During T cell development in the thymus, negative selection eliminates autoreactive and potentially harmful T cells, leading to central tolerance. This process, involves specific apoptosis programs thought to be governed by the transcription factor Nur77. To analyze the genetic pathways involved in ...
ORGANISM(S): Mus musculus 
2011-06-20 | E-TABM-550 | biostudies-arrayexpress
GenomicsIn-vitro selection-based identification of novel G-protein coupled receptors activating peptides
In-vitro selection of novel GPCR ligands
PRJEB65864 | ENA
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