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TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
TranscriptomicsGenome?wide analysis of pre?mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: A-seq
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome?wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37037 | biostudies-arrayexpress
TranscriptomicsCleavage Factor Im as a key regulator of 3’ UTR length
In eukaryotes, the 3' ends of RNA polymerase II-generated transcripts are made in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. By alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of t...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40137 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: CLIP
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome‐wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37398 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length
This SuperSeries is composed of the following subset Series: GSE37037: Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: A-seq GSE37398: Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role ...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-37401 | biostudies-arrayexpress
UnknownMotivation for Smoking Cessation in Patients With Oral Squamous Cell Carcinoma—A One‐Time Survey
Not available
S-EPMC12337751 | biostudies-literature
ProteomicsAn ancient lysozyme in placozoans
Lysozymes are an essential part of nutrition and antibacterial immunity in metazoans, executing the breakdown of bacterial cell walls via the hydrolysis of peptidoglycan. Although various lysozymes have been reported for several bilaterian phyla, the origin of metazoan lysozymes remains elusive as t...
ORGANISM(S): Trichoplax sp. H2 
2025-11-14 | PXD056545 | Pride
Lyozyme Pacozoan Trucnated 
TranscriptomicsGene expression profiling of liver biopsies from 21 chronic hepatitis C patients undergoing antiviral therapy
This dataset is part of the paper: Pegylated interferon-α regulates hepatic gene expression by transient activation of the Jak-STAT pathway; Dill MT et al; Journal of Clinical Investigation; in review Pegylated interferon-α (pegIFN-α) has replaced un-modified recombinant IFN-α for the treatment of c...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-48445 | biostudies-arrayexpress
MetabolomicsDissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata
Root-microbe interaction and its specialized root nodule structures and functions are well studied. In contrast, leaf nodules harboring microbial endophytes in special glandular leaf structures have only recently gained increased interest as plant-microbe phyllosphere interactions. Here, we applied ...
2021-08-26 | MTBLS2870 | MetaboLights
TranscriptomicsThe influence of resveratrol on rheumatoid fibroblast-like synoviocytes based on a gene chip transcription analysis
The aim of our study is to increase understanding of the antiproliferative and pro-apoptotic potency of resveratrol by identifying genes which underlie involved pathological pathways and biological process. Therefore, we performed a gene Chip Transcription Analysis with subsequent Protein ANalysis T...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-31685 | biostudies-arrayexpress
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