Gene expression profiling of liver biopsies from 21 chronic hepatitis C patients undergoing antiviral therapy

ABSTRACT: This dataset is part of the paper: Pegylated interferon-α regulates hepatic gene expression by transient activation of the Jak-STAT pathway; Dill MT et al; Journal of Clinical Investigation; in review Pegylated interferon-α (pegIFN-α) has replaced un-modified recombinant IFN-α for the treatment of chronic viral hepatitis because of its superior anti-viral efficacy that is generally attributed to improved pharmacokinetic properties. However, the pharmacodynamic effects of pegIFN-α in the liver have not been studied. We analyzed pegIFN-α induced signaling and gene regulation in paired liver biopsies obtained before treatment and during the first week after injection of pegIFN-α in 18 patients. Despite sustained high serum concentrations of pegIFN-α over the entire one-week dosing interval, I

ORGANISM(S): Homo sapiens

SUBMITTER: Zuzanna Makowska 

PROVIDER: E-GEOD-48445 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress