Sort   by:  
 Page size 
TranscriptomicsMethylation profiling by array of subcutaneous fat derived from 856 TwinsUK participants
Epigenetic changes such as DNA methylation variation are known to play a role in gene regulation and common disease susceptibility. Little is known about the genome-wide frequency, localization and function of such changes and how they are regulated by genetic and environmental factors. We have util...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1866 | biostudies-arrayexpress
GenomicsCharacterization of Functional Methylomes by Next-Generation Methylation Capture Sequencing
Comprehensive analysis of the human adipose epigenome by transcriptome, open chromatin and methylome sequencing studies.
ORGANISM(S): Homo sapiens 
2015-05-01 | E-MTAB-3181 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteoblast transcriptome in resting and induced primary cells
Osteoblasts are key players in bone remodeling. The accessibility of human primary osteoblast-like cells (HOb) from bone explants render them a lucrative model for studying molecular physiology of bone turnover, discovery of novel anabolic therapeutics and mesenchymal cell biology in general. Relati...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10311 | biostudies-arrayexpress
GenomicsPopulation-based whole-genome bisulfite sequencing in multiple human tissues
Analysis of human population methylome variation in adipose tissue and whole blood at single-site resolution by whole genome bisulfite sequencing.
ORGANISM(S): Homo sapiens 
2015-10-26 | E-MTAB-3549 | biostudies-arrayexpress
GenomicsMcGill-KCL WGBS
Data Access Committee EGAC00001000402
EGAC00001000402 | EGA
GenomicExpression QTL (eQTL) Analysis in Human Primary Cells

The common genetic variants associated with complex traits typically lie in non-coding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quanti...

phs000225 | dbGaP
TranscriptomicsGlobal analysis of the impact of environmental perturbation on cis-regulation of gene expression
This SuperSeries is composed of the following subset Series: GSE21410: Global analysis of the impact of environmental perturbation on cis-regulation of gene expression: BMP2, 2hr GSE21725: Global analysis of the impact of environmental perturbation on cis-regulation of gene expression: DEX, 24hr GSE...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-21728 | biostudies-arrayexpress
GenomicsA Population Genomics Study Using a Disease-Targeted Cell model: Integration of cis-eQTLs Discovered in Human Primary Osteoblasts with GWAS of Bone Phenotypes

The common genetic variants associated with complex traits typically lie in non-coding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quanti...

phs000225.v1.p1 | EGA
GenomicsCMH Genomics DAC
Data Access Committee EGAC00001001132
EGAC00001001132 | EGA
GenomicsPopulation whole-genome bisulfite sequencing across two tissues highlights environment as principal source of human methylome variation
The study includes whole-genome bisulfite sequencing (WGBS) on 34 adipose (7 MZ pairs, 6 DZ pairs and 8 singletons) and 27 blood (7 MZ pairs, 6 DZ pairs and 1 singleton) DNA samples derived from a total of 43 female twins belonging to the MuTHER/TwinsUK cohort. We generated 11.5 billion 100bp paired...
EGAS00001001569 | EGA
Sort   by:  
 Page size