Gruppuso Philip A PA

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Transcriptomics (3)
Proteomics (1)

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Rattus norvegicus (2)
Mus musculus (1)
Delftia acidovorans SPH-1 (1)
Cellulomonas gilvus ATCC 13127 (1)
Coprococcus comes ATCC 27758 (1)
Myxococcus xanthus DZ2 (1)
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Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 (1)
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Xylanibacter ruminicola 23 (1)
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Halomonas sp. (1)
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Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093 (1)
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bovine metagenome (1)

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biostudies-arrayexpress (3)
pride (1)

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Hepatocyte (1)
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Hepatocellular carcinoma (1)

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Mass Spectrometry (1)
Shotgun proteomics (1)

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2016 (1)
2013 (1)
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Study type

Transcription profiling by array (3)

Release Date

2016 (1)
2013 (1)
2010 (1)

Lab affiliation

Brown University (1)

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Regulation of Fetal Liver Growth in a Model of Diet Restriction in the Pregnant Rat

The present study was designed to test the hypothesis that limited growth of the fetal liver in the model of maternal fasting is independent of well-characterized signaling mechanisms that are known to regulate somatic growth in adult animals. We profiled the fetal hepatic transcriptome and translat...

ORGANISM(S): Rattus norvegicus

2016-07-18 | E-GEOD-77112 | biostudies-arrayexpress

Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma

We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target of rapamycin (mTOR) complex 1, markedly inhibits the growth of focal lesions in the resistant hepatocyte (Solt-Farber) model of hepatocellular carcinoma (HCC) in the rat. In the present study, we characterized...

ORGANISM(S): Rattus norvegicus (Rat)

2018-10-26 | PXD005845 | Pride

Expression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)

Recent work using mouse models has revealed that mTORC2, which unlike mTORC1 is not acutely sensitive to rapamycin, plays a key role in the regulation of organismal physiology. The substrates and pathways regulated by mTORC2 are at present relatively unknown Using a mouse model with a targeted delet...

ORGANISM(S): Mus musculus

2013-09-23 | E-GEOD-46515 | biostudies-arrayexpress

Rapamycin effect on gene expression: dependence on c-Myc

This experiment utilized rat fibroblasts that are wild-type for c-Myc (TGR-1 cells) and null for c-Myc (HO15.19 cells). Both were treated treated with rapamycin for 24 hr (comparison group, vehicle control). Cells were studied under conditions that supported proliferation. Rapamycin (50nM or DMSO ...