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ProteomicsProteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma
We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target of rapamycin (mTOR) complex 1, markedly inhibits the growth of focal lesions in the resistant hepatocyte (Solt-Farber) model of hepatocellular carcinoma (HCC) in the rat. In the present study, we characterized...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005845 | Pride
Proteomics Liver Hepatocellular carcinoma Laser capture microscopy Pre-neoplasia 
TranscriptomicsRegulation of Fetal Liver Growth in a Model of Diet Restriction in the Pregnant Rat
The present study was designed to test the hypothesis that limited growth of the fetal liver in the model of maternal fasting is independent of well-characterized signaling mechanisms that are known to regulate somatic growth in adult animals. We profiled the fetal hepatic transcriptome and translat...
ORGANISM(S): Rattus norvegicus 
2016-07-18 | E-GEOD-77112 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)
Recent work using mouse models has revealed that mTORC2, which unlike mTORC1 is not acutely sensitive to rapamycin, plays a key role in the regulation of organismal physiology. The substrates and pathways regulated by mTORC2 are at present relatively unknown Using a mouse model with a targeted delet...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-46515 | biostudies-arrayexpress
TranscriptomicsRapamycin effect on gene expression: dependence on c-Myc
This experiment utilized rat fibroblasts that are wild-type for c-Myc (TGR-1 cells) and null for c-Myc (HO15.19 cells). Both were treated treated with rapamycin for 24 hr (comparison group, vehicle control). Cells were studied under conditions that supported proliferation. Rapamycin (50nM or DMSO ...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-GEOD-18845 | biostudies-arrayexpress
TranscriptomicsDetermine the effects of mTORC1 inhibition by rapamycin on mouse liver transcriptome
Liver from RICTOR knockout mice show normal levels of mTORC1 signaling in response to refeeding. With this experiment we sought to compare the effects of Rictor depletion to the effects of mTORC1 inhibition by rapamycin in liver from mice that were fasted and refed. Mice were either fasted for 24hr...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-46582 | biostudies-arrayexpress
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